Teleost Caudal Fin Development and Regeneration: Mechanisms, Models, and Therapeutic Potential

Kalim Ullah *

Laboratory of Marine Biotechnology, School of Marine Sciences, Ningbo University, Zhejiang, China.

Rakhshanda Rani

Arid Agriculture University, Rawalpindi, Rawalpindi, Pakistan.

Fouzia Shaheen

Laboratory of Marine Biotechnology, School of Marine Sciences, Ningbo University, Zhejiang, China.

Faisal Tasleem *

Laboratory of Marine Biotechnology, School of Marine Sciences, Ningbo University, Zhejiang, China.

*Author to whom correspondence should be addressed.


Abstract

The caudal fin of teleost fish, a fundamental locomotive structure, has received considerable attention due to its extraordinary capacity for regeneration. Teleosts' ability to regenerate their caudal fins involves complex interactions between various signaling pathways, growth factors, and transcription factors that organize wound healing, cell proliferation, and tissue redevelopment. Key pathways implicated in these processes include Wnt/β-catenin, Hedgehog, FGF, and Notch signaling, which not only regulate the proliferation and differentiation of resident stem cells but also ensure the spatial and temporal coordination necessary for tissue architecture restoration. Moreover, on the practical challenges or limitations of translating these findings to human regenerative medicine would provide more balance. Looking forward, future research could benefit from advanced genomic and proteomic techniques to unravel the finer aspects of cellular dynamics and molecular diversity within the regenerative process of the caudal fin.

Keywords: Caudal fins, teleost, regeneration, development, fins therapeutic potential


How to Cite

Ullah, Kalim, Rakhshanda Rani, Fouzia Shaheen, and Faisal Tasleem. 2024. “Teleost Caudal Fin Development and Regeneration: Mechanisms, Models, and Therapeutic Potential”. Asian Journal of Fisheries and Aquatic Research 26 (12):1-11. https://doi.org/10.9734/ajfar/2024/v26i12840.